How older fathers affect their children's health and development
Effects of paternal aging on male reproductive biology and on future generations
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11076694
This study is looking at how getting older affects fathers' sperm and how that might impact the health of their future kids, with the goal of finding ways to lower health risks for children born to older dads.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11076694 on ClinicalTrials.gov |
What this research studies
This research investigates how aging in fathers impacts their reproductive biology and the health of their future children. It focuses on understanding the changes in sperm as men age, particularly looking at genetic and epigenetic alterations that may affect offspring. The study will analyze various male reproductive tissues and assess behavioral and metabolic traits in the children of older fathers. By exploring these factors, the research aims to uncover potential ways to reduce health risks associated with delayed fatherhood.
Who could benefit from this research
Good fit: Ideal candidates for this research are men of advanced paternal age who are considering fatherhood.
Not a fit: Patients who are not planning to have children or who are younger fathers may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to strategies that mitigate health risks in children born to older fathers.
How similar studies have performed: Other research has indicated that paternal age can influence offspring health, but this specific focus on epigenetic changes is relatively novel.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RANDO, OLIVER J — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: RANDO, OLIVER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.