How obstructive sleep apnea and HIV affect heart rhythm stability
Official title: Impact of Obstructive Sleep Apnea and HIV on Ventricular Repolarization Lability
Funded at University of Miami School of Medicine · NIH-11085474 · Data updated 2026-11-12
This study is looking at how obstructive sleep apnea affects heart rhythm in people with HIV, hoping to find ways to keep your heart healthier and reduce the risk of serious heart problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $115,125 |
| NIH project number | 1R21HL178402-01 |
| Project ID | NIH-11085474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also experience obstructive sleep apnea.
✕Less likely to help
Patients without HIV or those who do not have obstructive sleep apnea may not benefit from this research.
What this research studies
This research investigates the relationship between obstructive sleep apnea (OSA) and HIV, focusing on how these conditions impact heart rhythm stability. It aims to understand the mechanisms by which OSA, common among individuals with HIV, may lead to increased risks of serious heart issues, including sudden cardiac death. The study will analyze heart activity through electrocardiograms to measure fluctuations in heart rhythm, known as ventricular repolarization lability, which can indicate potential arrhythmias. By identifying these risks, the research seeks to improve health outcomes for patients living with HIV and OSA.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients with HIV and obstructive sleep apnea, reducing their risk of serious heart complications.
How similar studies have gone: Previous research has indicated a connection between sleep apnea and cardiovascular issues, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Herrera Aldana, Phabiola Macarena — University of Miami School of Medicine
- Study coordinator: Herrera Aldana, Phabiola Macarena
Related research
Other NIH-funded projects on the same topics.
-
Mechanisms of sex-specific responses to sleep apnea therapies
A research project at NYU School of Medicine is exploring how men and women may respond differently to treatments for obstructive sleep apnea and related heart risk.
-
Deep learning to predict obstruction site and guide sleep apnea treatment
A patient-focused project uses snoring sounds and AI to predict where your airway collapses during sleep and to guide personalized treatments.
-
Personalized DISE-guided surgery for sleep apnea in children with Down syndrome
A personalized surgical approach guided by DISE sleep-endoscopy is being tested to better treat sleep apnea in children with Down syndrome who don’t always improve after standard surgery.
-
Biomarkers to understand obstructive sleep apnea using microRNAs
A study at the University of Pennsylvania will look for microRNA signs in the blood that reflect how bad sleep apnea is and how well CPAP therapy works for patients.
-
Personalized sleep apnea care using genetics and biomarkers
A patient-friendly look at a research program aiming to tailor sleep apnea care using genetics, biomarkers, and brain/body signals to improve prediction and prevention.
-
Night-to-night sleep-disordered breathing differences in women and men
A study to find better biomarkers for sleep apnea severity, especially in women, by monitoring people at home for a week and tracking daily mood and energy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.