How obesity-related inflammation affects treatment response in rheumatoid arthritis patients
Obesity-Induced Inflammatory Mediators Predict Lack of Response in Patients with Rheumatoid Arthritis Starting Biological Therapies
This study is looking at how certain substances linked to obesity can help doctors figure out which rheumatoid arthritis treatments will work best for you, so they can personalize your care and improve your results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10781543 on NIH RePORTER |
What this research studies
This research investigates how inflammatory mediators related to obesity can predict the effectiveness of biological therapies in patients with rheumatoid arthritis (RA). The study aims to identify specific biomarkers that can help personalize treatment by determining which patients are likely to respond well to certain therapies. By analyzing a combination of proteins and lipids associated with obesity, researchers hope to uncover patterns that correlate with treatment outcomes. This approach seeks to improve the management of RA by tailoring therapies to individual patient profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with rheumatoid arthritis who are starting biological therapies and have varying levels of obesity.
Not a fit: Patients with rheumatoid arthritis who are not starting biological therapies or those without obesity-related inflammatory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with rheumatoid arthritis, improving their overall health outcomes.
How similar studies have performed: Previous studies have shown promise in identifying biomarkers for treatment response in rheumatoid arthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Guma, Monica — University of California, San Diego
- Study coordinator: Guma, Monica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.