How obesity affects the growth of the uterine lining and immune response
Official title: Obesity-induced endometrial stromal cell fibrosis and immunosuppression leads to increased endometrial hyperplasia disease severity
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11163601 · Data updated 2026-11-12
This study is looking at how being overweight can lead to a condition called endometrial hyperplasia, which can cause unusual bleeding and trouble getting pregnant, and it aims to find out more about the changes in the uterus that happen in women who are obese to help improve their care.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | May 16, 2025 |
| Project end | May 15, 2028 |
| Funding year | 2025 |
| Award (this year) | $42,187 |
| NIH project number | 1F31HD118753-01 |
| Project ID | NIH-11163601 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of childbearing age who are obese and experiencing symptoms related to endometrial hyperplasia.
✕Less likely to help
Patients who are not obese or do not have endometrial hyperplasia may not benefit from this research.
What this research studies
This research investigates the relationship between obesity and endometrial hyperplasia (EH), a condition that can lead to abnormal bleeding and infertility in women. It focuses on how obesity causes hormonal imbalances that promote EH and examines the role of endometrial stromal cell fibrosis and immunosuppression in this process. By using advanced techniques like single-cell RNA sequencing, the study aims to identify specific genetic changes in the uterine tissue of obese individuals. The ultimate goal is to understand the mechanisms behind obesity-related EH to improve diagnosis and treatment options for affected women.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of endometrial hyperplasia in obese women, potentially improving fertility and reducing abnormal bleeding.
How similar studies have gone: While the specific mechanisms being studied are novel, previous research has shown that obesity can influence hormonal levels and related conditions, indicating potential for significant findings.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Skalski, Hilary — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Skalski, Hilary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.