How obesity affects the ability of stem cells to repair blood vessels
Obesity-induced dysfunction of human MSC in peripheral microvascular repair
This study looks at how being overweight affects special cells in your body that help repair blood vessels and tissues, with the goal of finding ways to improve healing for people dealing with health issues related to obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10872172 on NIH RePORTER |
What this research studies
This research investigates how obesity impacts the function of mesenchymal stem cells (MSCs), which are crucial for repairing blood vessels and tissues. The study focuses on understanding the cellular and molecular mechanisms that lead to MSC dysfunction in obese individuals, particularly how obesity alters mitochondrial function and gene expression in these cells. By examining these processes, the research aims to uncover potential therapeutic targets to enhance tissue repair in patients suffering from obesity-related vascular complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and experiencing complications related to peripheral vascular disease.
Not a fit: Patients who are not obese or do not have any vascular complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with obesity-related vascular diseases, enhancing their recovery and quality of life.
How similar studies have performed: Previous research has shown that targeting stem cell function can lead to significant improvements in tissue repair, suggesting that this approach may hold promise for similar advancements.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lerman, Lilach O — Mayo Clinic Rochester
- Study coordinator: Lerman, Lilach O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.