How obesity affects ovarian signaling and fertility in women
Investigating obesity-induced altered ovarian intracellular signaling
This study looks at how being overweight can change the way ovarian cells react to chemicals in the environment, which might lead to problems like infertility and early menopause in women, and it aims to help us understand the risks for women who are obese and their future children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-10953940 on NIH RePORTER |
What this research studies
This research investigates how obesity alters the way ovarian cells respond to environmental chemicals, which can lead to reproductive issues such as infertility and premature menopause in women. The study focuses on understanding the mechanisms behind these changes, particularly how obesity affects the metabolism of chemicals in the ovary and the body's ability to repair DNA damage. By using animal models, the researchers aim to uncover the risks that obese women face regarding their reproductive health and the health of their offspring. The findings could provide insights into the long-term health complications associated with obesity in women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who are classified as obese and may be experiencing reproductive health issues.
Not a fit: Patients who are not obese or those who do not have reproductive health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of reproductive health issues in obese women, potentially reducing infertility rates and associated health complications.
How similar studies have performed: Previous studies have shown that obesity can significantly impact reproductive health, indicating that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Keating, Aileen Frances — Iowa State University
- Study coordinator: Keating, Aileen Frances
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.