How obesity affects muscle protein types in humans
Regulation of Muscle Protein Phenotype in Humans with Obesity
This study is looking at how being overweight affects the proteins in your muscles, especially those that help them work properly, to see if understanding these changes can lead to better muscle health for people with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10665575 on NIH RePORTER |
What this research studies
This research investigates how obesity alters the types of muscle proteins, specifically focusing on the myosin heavy chain (MHC) isoforms that are crucial for muscle function. By comparing the muscle protein profiles of individuals with obesity to those of lean individuals, the study aims to understand the biological mechanisms that lead to reduced Type I muscle fibers, which are important for glucose uptake and insulin sensitivity. The researchers will analyze protein turnover and gene expression related to these muscle proteins to uncover insights that could help improve muscle health in obese individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with obesity who are interested in understanding how their condition affects muscle health.
Not a fit: Patients who are not affected by obesity or have other significant metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing muscle function and metabolic health in individuals with obesity.
How similar studies have performed: Previous research has shown that understanding muscle protein dynamics can lead to significant advancements in treating obesity-related metabolic issues, indicating that this approach has potential for success.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Katsanos, Christos S — Arizona State University-Tempe Campus
- Study coordinator: Katsanos, Christos S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.