How obesity affects lung immune cells and inflammation
Official title: Impact of Obesity on Lung Macrophage Metabolism and Inflammation
Funded at Children's Hosp of Philadelphia · NIH-10984960 · Data updated 2026-11-12
This study is looking at how obesity affects certain immune cells in the lungs that are important for inflammation and asthma, to help us understand why asthma can be worse for people who are obese and to find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $540,803 |
| NIH project number | 5R01HL162715-03 |
| Project ID | NIH-10984960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are obese and have been diagnosed with asthma.
✕Less likely to help
Patients who are not obese or do not have asthma may not receive any benefit from this research.
What this research studies
This research investigates the impact of obesity on lung macrophages, which are immune cells that play a crucial role in inflammation and asthma. By studying how these cells respond to inflammatory signals in obese individuals, the research aims to uncover the unique immunological challenges faced by patients with obesity-associated asthma. The approach includes examining lung tissue samples and using advanced techniques to analyze the metabolic changes in these immune cells. The goal is to better understand the mechanisms that lead to more severe asthma in obese patients, potentially paving the way for new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from obesity-associated asthma.
How similar studies have gone: Other research has shown promising results in understanding the relationship between obesity and immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Hill, David Andrew — Children's Hosp of Philadelphia
- Study coordinator: Hill, David Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.