How obesity affects immune cell behavior in septic surgical patients
Official title: The impact of obesity on neutrophil swarming in septic surgical patients
Funded at Ohio State University · NIH-11033517 · Data updated 2026-11-12
This study is looking at how obesity affects the immune system in patients who have surgery and get an infection called sepsis, with the goal of finding ways to help both overweight and normal-weight patients fight infections better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $190,620 |
| NIH project number | 1K08GM157658-01 |
| Project ID | NIH-11033517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are surgical patients who are either obese or lean and have developed sepsis.
✕Less likely to help
Patients who are not undergoing surgery or do not have sepsis may not benefit from this research.
What this research studies
This research investigates the relationship between obesity and immune response in patients undergoing surgery who develop sepsis. It focuses on how fat cells release specific molecules that alter the behavior of immune cells called neutrophils, which are crucial for fighting infections. The study aims to understand the mechanisms behind these changes and explore potential treatments to improve immune function in both obese and lean patients. By examining these interactions in a controlled laboratory setting, the researchers hope to identify ways to enhance neutrophil activity and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for septic surgical patients, particularly those who are obese, enhancing their immune response and survival rates.
How similar studies have gone: Previous research has indicated that targeting immune cell behavior can improve outcomes in septic patients, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Jalilvand, Anahita — Ohio State University
- Study coordinator: Jalilvand, Anahita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.