How obesity affects glucose transport and metabolism in the brain
The impact of obesity on cerebral glucose transport and metabolism
This study is looking at how being overweight might affect the brain's ability to use sugar for energy, and it's for anyone interested in understanding how obesity can impact brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10813776 on NIH RePORTER |
What this research studies
This research investigates the relationship between obesity and brain metabolism, specifically focusing on how obesity may reduce the brain's ability to transport glucose across the blood-brain barrier. Using advanced neuroimaging techniques and metabolic assessments, the study aims to uncover the mechanisms behind this association, including the role of fatty acids in glucose transport. The research includes both human participants and animal models to provide a comprehensive understanding of the effects of obesity on brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are obese or have a body mass index (BMI) indicating obesity.
Not a fit: Patients who are not obese or do not have related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how obesity impacts brain health and may inform strategies for preventing or treating cognitive decline in obese individuals.
How similar studies have performed: Previous research has indicated a link between obesity and reduced brain metabolism, suggesting that this study builds on established findings but explores new mechanisms.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Hwang, Janice Jin — Univ of North Carolina Chapel Hill
- Study coordinator: Hwang, Janice Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.