How obesity affects exercise responses in humans
Official title: Exercise Response in Humans with Obesity
Funded at Mayo Clinic Rochester · NIH-11088935 · Data updated 2026-11-12
This study is looking at how inflammation in fat tissue affects how people with obesity respond to exercise, and it’s for anyone interested in understanding how their body works during workouts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $697,543 |
| NIH project number | 5R01DK133194-03 |
| Project ID | NIH-11088935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with obesity who are willing to participate in exercise assessments and tissue sampling.
✕Less likely to help
Patients without obesity or those who are unable to participate in exercise due to medical conditions may not benefit from this research.
What this research studies
This research investigates the impact of inflamed adipose tissue on exercise responses in individuals with obesity. It aims to understand how inflammation in fat tissue can disrupt muscle function and biochemical responses to exercise. Participants will undergo assessments that include measuring protein synthesis rates and analyzing gene activity in skeletal muscle after exercise. The study will also explore how different types of fat tissue influence these responses through laboratory experiments with muscle and fat cell cultures.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise strategies and treatments for individuals with obesity, enhancing their overall health and fitness.
How similar studies have gone: Previous research has shown that inflammation in adipose tissue can negatively affect muscle function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Lanza, Ian R — Mayo Clinic Rochester
- Study coordinator: Lanza, Ian R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.