How obesity affects cancer treatment in endometrial cancer patients
Impact of Obesity on Immuno-Oncology Agents in Endometrial Cancer
This study is looking at how being overweight affects the success of certain cancer treatments for women with endometrial cancer, and it aims to find better ways to help those patients by combining two specific medications.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10672881 on NIH RePORTER |
What this research studies
This research investigates the impact of obesity on the effectiveness of immuno-oncology treatments for endometrial cancer. It focuses on how obesity influences the immune response and the expression of specific proteins that are targeted by cancer therapies. The study will explore the combination of atezolizumab, an anti-PD-L1 antibody, with ONC201, a small molecule that may enhance treatment efficacy. By understanding these interactions, the research aims to improve treatment outcomes for obese patients with endometrial cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese patients diagnosed with endometrial cancer.
Not a fit: Patients who are not obese or do not have endometrial cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments for obese patients with endometrial cancer.
How similar studies have performed: Other research has shown promising results with immuno-oncology treatments in similar contexts, but this specific approach is relatively novel.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Bae-Jump, Victoria Lin — Univ of North Carolina Chapel Hill
- Study coordinator: Bae-Jump, Victoria Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.