How obesity affects cancer treatment in endometrial cancer patients

Who could benefit from this research

What this research studies

This research investigates the impact of obesity on the effectiveness of immuno-oncology treatments for endometrial cancer. It focuses on how obesity influences the immune response and the expression of specific proteins that are targeted by cancer therapies. The study will explore the combination of atezolizumab, an anti-PD-L1 antibody, with ONC201, a small molecule that may enhance treatment efficacy. By understanding these interactions, the research aims to improve treatment outcomes for obese patients with endometrial cancer.

Why it matters

Where this research is happening

• Univ of North Carolina Chapel Hill
  Chapel Hill, United States Active

Researchers

• Principal investigator: Bae-Jump, Victoria Lin — Univ of North Carolina Chapel Hill
• Study coordinator: Bae-Jump, Victoria Lin

Related research

Other NIH-funded projects on the same topics.

• Obesity-related metabolic changes and disparities in endometrial cancer

  This project looks at why endometrial cancer is worse for Black women and whether obesity-related metabolic changes drive the disease, with aims to find ways to prevent or slow progression.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11419268

• Investigating how obesity affects protein quality control in endometrial cancer

  This study is looking at how being overweight might affect the way cancer cells in the uterus work, especially in women with endometrial cancer, to help find better ways to prevent and treat this type of cancer.

  NIH research Wayne State University · Detroit, United States · NIH-10980557

• Investigating how progesterone receptors work in obesity to prevent endometrial cancer

  This study is looking at how being overweight might affect the way certain hormones work in the uterus, especially in women at risk for endometrial cancer, to find out how we can better prevent this type of cancer.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10889094

• Investigating how obesity affects the response to metformin in endometrial cancer

  This study is looking at how the diabetes medication metformin might help treat endometrial cancer in people with obesity and diabetes, and it aims to find out which patients could benefit the most from this treatment.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10790007

• Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

  This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

• Understanding how maternal and infant sleep and daily rhythms influence early appetite and obesity risk

  This project explores how infant sleep, circadian rhythms, and maternal-infant timing relate to early appetite patterns and the risk of obesity in the first year of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11628798

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.