How nutrition affects hormone release related to reproduction
Nutritional Regulation of Luteinizing Hormone Secretion
['FUNDING_R01'] · COLORADO STATE UNIVERSITY · NIH-11200469
This study looks at how not getting enough food and then eating again affects important hormones that control reproduction in sheep, helping us understand how nutrition influences when they reach puberty and how successful they are in reproducing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-11200469 on ClinicalTrials.gov |
What this research studies
This research investigates how undernutrition and subsequent re-feeding influence the secretion of key reproductive hormones in sheep. By examining the mechanisms that regulate gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), the study aims to understand how energy intake impacts puberty onset and reproductive success. The research will utilize animal models to explore the roles of specific signaling pathways and immune cells in hormone regulation during periods of nutritional stress and recovery.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals or populations experiencing reproductive challenges related to nutritional status.
Not a fit: Patients who are not experiencing reproductive issues or who have no concerns related to nutrition may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing reproductive health in livestock and potentially inform human reproductive health practices.
How similar studies have performed: While this research explores novel mechanisms, similar studies have shown that nutrition significantly impacts reproductive hormone regulation in various species.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NESTOR, CASEY C — COLORADO STATE UNIVERSITY
- Study coordinator: NESTOR, CASEY C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.