How nutrient signals control gene expression and growth in cells
Official title: Post-transcriptional control of gene expression by the mTORC1 signaling pathway
Funded at Yale University · NIH-10765415 · Data updated 2026-11-12
This study is looking at how a specific pathway in our cells helps them use nutrients to make proteins, which is important for growth and health, and it hopes to find out how this process relates to diseases like cancer and diabetes, so that patients can benefit from better understanding and treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 8, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 1R35GM152167-01 |
| Project ID | NIH-10765415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancers or metabolic disorders linked to mTORC1 signaling.
✕Less likely to help
Patients with conditions unrelated to cellular growth regulation or mTORC1 signaling may not receive any benefit from this research.
What this research studies
This research investigates the mTORC1 signaling pathway, which plays a crucial role in regulating how cells translate genetic information into proteins. By examining how this pathway responds to nutrient signals, the research aims to uncover the mechanisms that control gene expression and cellular function. The study focuses on understanding the differences between cap-dependent and cap-independent translation of mRNAs, which are vital for cellular growth and function. Patients may benefit from insights gained about how these processes are linked to diseases such as cancer and diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular growth and function, including various cancers and metabolic disorders.
How similar studies have gone: Previous research has shown success in understanding the mTORC1 pathway and its implications in various diseases, indicating that this approach is built on established findings.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Thoreen, Carson Cornell — Yale University
- Study coordinator: Thoreen, Carson Cornell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.