How nutrient sensing affects protein translation in diseases like Alzheimer's and cancer
Regulation of Translation by O-GlcNAc - Resubmission 03-05-2020
This study is looking at how a special sugar modification on proteins affects how our cells work, especially when it comes to diseases like Alzheimer's, diabetes, and cancer, to help find new ways to understand and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10747332 on NIH RePORTER |
What this research studies
This research investigates the role of O-GlcNAcylation, a process where a sugar molecule modifies proteins, in regulating protein translation and cellular functions. By examining how nutrients and stress influence this modification, the study aims to uncover mechanisms that contribute to chronic diseases such as Alzheimer's disease, diabetes, and cancer. The researchers will utilize advanced mass spectrometry techniques to identify proteins involved in translation that are affected by O-GlcNAcylation. This understanding could lead to new insights into how cellular processes are disrupted in these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or other neurodegenerative disorders.
Not a fit: Patients with acute conditions unrelated to aging or metabolic processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other age-related conditions.
How similar studies have performed: Other research has shown promising results in understanding the role of protein modifications in chronic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Hart, Gerald Warren — University of Georgia
- Study coordinator: Hart, Gerald Warren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.