How nutrient delivery affects weight loss and brain signaling after bariatric surgery
Official title: Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery
Funded at Lsu Pennington Biomedical Research Ctr · NIH-11143895 · Data updated 2026-11-12
This study is looking at how quickly nutrients reach the gut and how that affects weight loss and brain signals in people having bariatric surgery, to help us understand how gut health can influence feelings of fullness and food choices.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $178,740 |
| NIH project number | 5K23DK138261-02 |
| Project ID | NIH-11143895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are being evaluated for bariatric surgery and have obesity.
✕Less likely to help
Patients who are not considering bariatric surgery or do not have obesity may not benefit from this research.
What this research studies
This research investigates how the rate at which nutrients are delivered to the gut influences weight loss and brain signaling in individuals undergoing bariatric surgery. It aims to understand the gut-brain axis, which connects gut health and brain function, particularly focusing on how rapid nutrient delivery can enhance feelings of fullness and alter food preferences. Participants will receive a glucose infusion through a feeding tube placed in the small intestine while their brain responses are monitored using advanced imaging techniques. This approach seeks to uncover the mechanisms that contribute to sustained weight loss after surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for weight management and obesity treatment through enhanced understanding of gut-brain interactions.
How similar studies have gone: Previous research has shown promising results in understanding the gut-brain axis and its role in weight loss, indicating that this approach has potential for significant findings.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Albaugh, Vance L — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Albaugh, Vance L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.