How nutrient availability affects T cell development and immune function
The hexosamine biosynthesis pathway in metabolism and cell fate
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10799084
This study is looking at how certain cells in your immune system, called T cells, decide what to do based on their genes, signals from other cells, and the nutrients they get, with the goal of finding ways to improve your immune health through better diet.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10799084 on ClinicalTrials.gov |
What this research studies
This research investigates how cells, particularly T cells, determine their fate based on genetic factors, cellular signals, and nutrient availability. It focuses on the hexosamine biosynthesis pathway, which is crucial for synthesizing T cell receptors that help the immune system recognize pathogens. By understanding how this pathway influences metabolism and signaling, the research aims to develop dietary strategies that could enhance immune function. Patients may benefit from insights that could lead to improved immune responses through nutritional interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in how nutrition impacts immune health, particularly those with immune system disorders.
Not a fit: Patients with established immune conditions that do not respond to dietary changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary strategies that enhance immune system function, potentially improving health outcomes for patients.
How similar studies have performed: Other research has shown promising results in manipulating metabolic pathways to enhance immune function, suggesting this approach has potential.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACINTO, ESTELA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: JACINTO, ESTELA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.