How nutrient availability affects gene regulation in cells
Mechanisms of Target of Rapamycin Complex 1 Dependent Epigenetic Regulation
This study is looking at how nutrients affect our genes and their activity, using yeast to learn more about how this process works, which could help us understand diseases like cancer and improve health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10874599 on NIH RePORTER |
What this research studies
This research investigates how nutrients influence gene regulation through epigenetic mechanisms, particularly focusing on the mTORC1 signaling pathway. By using a yeast model, the study aims to uncover how nutrient signals affect chromatin structure and gene expression, which is crucial for understanding diseases like cancer. The research will explore specific pathways that help cells adapt to nutrient stress and maintain their viability. Patients may benefit from insights gained about how nutrient regulation impacts health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by nutrient signaling and metabolism, particularly those with cancer.
Not a fit: Patients with conditions unrelated to nutrient metabolism or epigenetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases related to nutrient signaling, such as cancer.
How similar studies have performed: Other research has shown promising results in understanding nutrient signaling pathways, making this approach a continuation of established scientific inquiry.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Laribee, Ronald — University of Tennessee Health Sci Ctr
- Study coordinator: Laribee, Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.