How nucleosomes affect the early stages of gene transcription
The effect of nucleosomes on the earliest stages of RNA polymerase II transcription
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11136541
This study looks at how tiny structures in our DNA called nucleosomes affect the process of turning genes on and off, helping us understand why some genes work well while others don’t, which could be helpful for anyone interested in gene expression and its impact on health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11136541 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nucleosomes in the early stages of gene transcription, specifically focusing on how they influence the assembly of the RNA polymerase II complex and its ability to elongate. By examining the interactions between nucleosomes and transcription factors, the study aims to uncover the mechanisms that determine whether transcription will proceed effectively or terminate prematurely. The research employs biochemical techniques to dissect these processes in a controlled laboratory setting, providing insights into the fundamental aspects of gene expression regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to gene transcription or chromatin structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, potentially informing new therapeutic strategies for diseases linked to gene expression abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding gene transcription mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUSE, DONAL — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: LUSE, DONAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.