How nuclear receptor signaling affects stem cell lineages in tissues
Official title: Regulation of tissue stem cell lineages by nuclear receptor signaling
Funded at Trustees of Indiana University · NIH-10903963 · Data updated 2026-11-12
This study looks at how certain proteins in our cells help control stem cells in the ovaries of fruit flies, and it aims to understand how these proteins influence the health and repair of tissues, which could be important for people interested in how our bodies maintain themselves.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $379,398 |
| NIH project number | 5R35GM150517-02 |
| Project ID | NIH-10903963 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may have conditions affecting tissue maintenance or stem cell function.
✕Less likely to help
Patients over 21 years old or those with conditions unrelated to stem cell function may not benefit from this research.
What this research studies
This research investigates the role of nuclear receptors in regulating stem cell lineages, particularly focusing on how these receptors influence tissue maintenance and repair. By using the Drosophila melanogaster ovary as a model, the study aims to understand how communication between different organs, mediated by nuclear receptor signaling, affects germline stem cell behavior. The research will explore the mechanisms by which these receptors impact fat cell metabolism and hormone levels, which in turn may affect stem cell function and tissue homeostasis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to maintain healthy tissue function and potentially improve treatments for conditions related to stem cell dysfunction.
How similar studies have gone: While the specific approach using Drosophila melanogaster is novel, previous research has shown that nuclear receptors play significant roles in stem cell regulation and tissue homeostasis.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Weaver, Lesley Nicole — Trustees of Indiana University
- Study coordinator: Weaver, Lesley Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.