How nuclear actin affects aging and gene expression
When actin’s not actin like actin: Nuclear actin impacts transcription and aging
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11167302
This study is looking at how a special protein called nuclear actin affects aging and how our genes work, using tiny worms to see how it helps with DNA repair and cell health when they face stress or get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11167302 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nuclear actin in cellular processes related to aging and gene expression. By developing new methods to visualize and study nuclear actin, the project aims to understand its impact on DNA repair and transcription regulation in the model organism C. elegans. The researchers will explore how changes in nuclear actin function during stress and aging can influence cellular health. This innovative approach seeks to fill a significant gap in our understanding of actin's role beyond the cytoplasm.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or diseases.
Not a fit: Patients with acute, non-age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into aging and age-related diseases, potentially informing therapeutic strategies.
How similar studies have performed: While the study of nuclear actin is a relatively new field, preliminary research suggests that understanding its role could lead to significant advancements in aging research.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HIGUCHI-SANABRIA, RYO — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: HIGUCHI-SANABRIA, RYO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder