How NSAID pain medicines affect kidney health
Official title: Non-SteroidAl Impact on Kidney Disease Study (NSAIDS)
Funded at Northern California Institute/res/edu · NIH-11325408 · Data updated 2026-11-12
This project will test blood and urine biomarker checks to spot early kidney harm from common NSAID pain medicines in adults who use them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $649,224 |
| NIH project number | 5R01DK132640-04 |
| Project ID | NIH-11325408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who regularly use NSAID pain medicines, including people with or at higher risk for chronic kidney disease, would be the ideal candidates.
✕Less likely to help
People who do not take NSAIDs or who already have end-stage kidney disease on dialysis are unlikely to benefit directly from this work.
What this research studies
Researchers will collect blood and urine samples from adults who take NSAID pain medicines and measure multiple kidney biomarkers to build a monitoring panel. The panel is designed to detect injury in the kidney tubules that standard creatinine tests often miss and to identify patterns specifically linked to NSAID use. The team will use these markers to forecast who may experience future declines in kidney function. If the panel works, it could help doctors catch problems earlier and make safer pain-treatment choices.
Why it matters
Potential benefit: Could allow earlier detection of NSAID-related kidney injury so patients can be treated more safely or switch to safer pain options sooner.
How similar studies have gone: Some kidney injury biomarkers have shown promise in other settings (like surgical or drug-related injury), but using a tailored panel specifically for NSAID-related tubular damage is relatively novel.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Estrella, Michelle M — Northern California Institute/res/edu
- Study coordinator: Estrella, Michelle M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.