How NRF2 affects inflammation and tumor growth in breast cancer
NRF2 suppression of inflammatory signaling and its role in tumor progression
['FUNDING_R01'] · FRED HUTCHINSON CANCER CENTER · NIH-10943799
This study is looking at how a protein called NRF2 affects the growth and spread of breast cancer, with the hope of finding new ways to help prevent or treat it, so that patients can have better options for managing their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10943799 on ClinicalTrials.gov |
What this research studies
This research investigates the role of NRF2, a transcription factor, in the spread and recurrence of breast cancer. By examining how NRF2 influences cancer cell survival and metastasis, the study aims to uncover new therapeutic pathways that could prevent or treat metastatic breast cancer. The approach includes analyzing tumor samples and utilizing advanced techniques like CRISPR to understand the molecular mechanisms at play. Patients may benefit from insights that could lead to more effective treatments targeting tumor recurrence and spread.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with breast cancer, particularly those at risk of metastasis or recurrence.
Not a fit: Patients with non-epithelial cancers or those who are not currently diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of breast cancer recurrence and metastasis.
How similar studies have performed: Other research has shown promising results in targeting NRF2 pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALVAREZ, JAMES V — FRED HUTCHINSON CANCER CENTER
- Study coordinator: ALVAREZ, JAMES V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell, Breast Cancer Model