How NOTCH1 affects the growth of endometriosis lesions
Regulation of Endometriotic Lesion Development by NOTCH1
This study is looking at how a protein called NOTCH1 affects the growth of endometriosis lesions, which can cause pelvic pain and trouble getting pregnant, using baboons to find out how inflammation impacts this process, with hopes of discovering new treatments for women dealing with endometriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11044076 on NIH RePORTER |
What this research studies
This research investigates the role of NOTCH1 in the development of endometriotic lesions, which are a significant cause of pelvic pain and infertility in women. By using a baboon model, the study aims to understand how inflammatory signals influence NOTCH1 expression and subsequently affect lesion growth. The researchers will explore the cellular mechanisms involved, which could lead to new targeted therapies for endometriosis. This approach is designed to provide insights that are difficult to obtain from human studies due to diagnostic delays.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who are diagnosed with endometriosis and experience symptoms such as pelvic pain or infertility.
Not a fit: Patients who do not have endometriosis or are beyond reproductive age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively prevent or reduce the symptoms of endometriosis.
How similar studies have performed: Previous research has shown promising results in understanding endometriosis through animal models, indicating that this approach has potential for success.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Fazleabas, Asgerally T. — Michigan State University
- Study coordinator: Fazleabas, Asgerally T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.