How Notch signaling affects stem cell function in the fetal liver
Official title: Notch signaling regulates stem cell function in the fetal liver hematopoietic niche
Funded at University of Illinois at Chicago · NIH-11062510 · Data updated 2026-11-12
This study is looking at how a special signaling process called Notch affects blood stem cells in the fetal liver, with the goal of finding ways to make these cells work better for transplants, which could help patients have more successful treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $288,593 |
| NIH project number | 5R01DK137093-02 |
| Project ID | NIH-11062510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions requiring stem cell transplants, particularly those under 21 years old.
✕Less likely to help
Patients with conditions unrelated to hematopoietic stem cell function or those over 21 years old may not receive benefit from this research.
What this research studies
This research investigates the role of Notch signaling in the function of hematopoietic stem cells (HSCs) found in the fetal liver. By examining how Notch signaling influences the growth and functionality of these stem cells, the researchers aim to uncover mechanisms that could enhance their use in transplants. The study will utilize advanced techniques to identify specific subsets of HSCs that may have superior capabilities, potentially leading to improved outcomes in stem cell therapies. Patients may benefit from insights gained about how to optimize stem cell function for better transplant success.
Why it matters
Potential benefit: If successful, this research could lead to improved stem cell therapies for patients requiring transplants.
How similar studies have gone: Previous studies have shown promising results regarding the role of Notch signaling in stem cell function, indicating that this approach has potential for success.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Pajcini, Kostandin — University of Illinois at Chicago
- Study coordinator: Pajcini, Kostandin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.