How Notch signaling affects blood vessel function
Arterial Vasoregulation by Notch Signaling
This study is looking at how a specific signaling system in our bodies helps control how blood vessels tighten and relax, which is important for keeping blood pressure healthy, and it aims to find new ways to understand and treat vascular diseases that affect patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10854731 on NIH RePORTER |
What this research studies
This research investigates the role of Notch signaling in regulating the function of blood vessels, focusing on how it influences both constriction and relaxation of arteries. By studying the interactions between smooth muscle and endothelial cells, the research aims to uncover the molecular mechanisms that control blood pressure and vascular health. The team will explore how specific Notch ligands and receptors contribute to these processes, potentially leading to new insights into vascular diseases. Patients may benefit from a better understanding of how blood flow is regulated in their bodies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hypertension or other vascular-related conditions.
Not a fit: Patients with stable vascular health and no history of blood pressure issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to abnormal blood pressure and vascular dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding vascular signaling pathways, suggesting that this approach could yield significant insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Proweller, Aaron — Case Western Reserve University
- Study coordinator: Proweller, Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.