How Notch controls cell communication
Dynamics of Notch Signaling
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11159679
This project maps how Notch signaling molecules move and interact inside cells to help people with diseases such as cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11159679 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers are using new imaging and molecular tagging tools to watch Notch signaling happen in living cells. They combine light-sheet microscopy, proximity labeling, and CRISPR-based tagging to follow the timing and location of receptors and ligands. The team will create computer visualization tools to assemble these events into clear, time-resolved pictures in both normal and disease-like conditions. Those methods are designed to be shared so other researchers can study signaling in a range of diseases.
Who could benefit from this research
Good fit: Patients with cancers or developmental disorders known to involve Notch signaling would be the most likely to benefit or be contacted for future related studies.
Not a fit: People with health problems unrelated to Notch signaling are unlikely to see direct benefits from this basic lab-focused work.
Why it matters
Potential benefit: If successful, this work could reveal how Notch misregulation drives cancer and point to new molecular targets or strategies for therapy.
How similar studies have performed: Notch signaling has a long research history, but combining live-cell light-sheet imaging with proximity labeling and CRISPR tagging to get time-resolved molecular dynamics is a relatively new and promising approach.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLACKLOW, STEPHEN C. — HARVARD MEDICAL SCHOOL
- Study coordinator: BLACKLOW, STEPHEN C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.