How norovirus evades the immune system in the intestines
Official title: Viral immune evasion during intestinal norovirus infection
Funded at Brown University · NIH-11051133 · Data updated 2026-11-12
This study is looking at how norovirus, which causes stomach bugs, tricks our body's defenses in the intestines, using mice to learn more about how the virus hides from our immune system, and the goal is to find new ways to help people fight off these infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | March 6, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $550,696 |
| NIH project number | 5R01AI183155-02 |
| Project ID | NIH-11051133 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced gastrointestinal infections, particularly those caused by norovirus.
✕Less likely to help
Patients with non-viral gastrointestinal issues or those who do not have a history of norovirus infection may not benefit from this research.
What this research studies
This research investigates how norovirus, a common cause of gastrointestinal infections, evades the immune response in the intestines. By using a mouse model, the study focuses on the role of specific receptors on epithelial cells that the virus targets to suppress immune signaling. The researchers aim to understand the interactions between the virus and these cells, particularly how the viral protein NS1 interferes with the body's ability to detect and respond to the infection. This could lead to new insights into viral infections and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for norovirus infections and enhance our understanding of viral immune evasion.
How similar studies have gone: Previous research has shown success in understanding viral immune evasion mechanisms, making this approach promising but still exploring novel aspects.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Lee, Sanghyun — Brown University
- Study coordinator: Lee, Sanghyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.