How non-nutritive sweeteners affect the gut microbiome and metabolic health
The role of non-nutritive sweeteners-microbiome interactions in the pathogenesis of metabolic syndrome
This study is looking at how sugar substitutes, like non-nutritive sweeteners, might affect the good bacteria in your gut and could be linked to health issues like type 2 diabetes and heart disease, and it invites people to participate in trials to see how these sweeteners interact with their own gut health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10914125 on NIH RePORTER |
What this research studies
This research investigates the impact of non-nutritive sweeteners (NNS) on the gut microbiome and their potential role in causing metabolic syndrome, including type 2 diabetes and cardiovascular diseases. The study examines how these sweeteners, often used as sugar substitutes, may disrupt gut bacteria and lead to glucose intolerance. By analyzing individual responses based on pre-existing microbiome composition, the research aims to uncover the mechanisms behind these effects. Patients may be involved in clinical trials to better understand their unique interactions with NNS.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals who consume non-nutritive sweeteners and are at risk for metabolic syndrome or related conditions.
Not a fit: Patients who do not consume non-nutritive sweeteners or have no metabolic health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized dietary recommendations that improve metabolic health and reduce the risk of diabetes and cardiovascular diseases.
How similar studies have performed: Previous studies have indicated that dietary components can significantly influence metabolic health, suggesting that this research could build on established findings, although the specific focus on NNS and microbiome interactions is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Suez, Jotham — Johns Hopkins University
- Study coordinator: Suez, Jotham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.