How non-coding RNAs influence gene regulation and inheritance across generations
Official title: Non-Coding RNAs in Gene Regulation, Genome Defense, and Epigenetic Inheritance
Funded at Harvard Medical School · NIH-10841475 · Data updated 2026-11-12
This study is looking at tiny RNA molecules that don't code for proteins but help control how genes work, and it's using a small worm called C. elegans to see how these molecules might pass information from one generation to the next, which could help us understand some diseases caused by gene regulation issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $667,970 |
| NIH project number | 5R35GM148206-02 |
| Project ID | NIH-10841475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by epigenetic factors.
✕Less likely to help
Patients with conditions unrelated to gene regulation or epigenetic processes may not benefit from this research.
What this research studies
This research investigates the role of non-coding RNAs in regulating gene expression and their potential to transmit epigenetic information across generations. Using the model organism C. elegans, the study aims to understand how these RNA molecules orchestrate complex biological processes during reproduction and development. The research employs advanced genetic screening and molecular biology techniques to explore the mechanisms by which non-coding RNAs affect chromatin states and gene regulation. By uncovering these pathways, the study seeks to provide insights into the causes of diseases linked to epigenetic misregulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases caused by epigenetic misregulation.
How similar studies have gone: Previous research has shown promising results in understanding the role of non-coding RNAs in gene regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Kennedy, Scott G — Harvard Medical School
- Study coordinator: Kennedy, Scott G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.