How non-coding RNAs affect gene expression and behavior related to alcohol use disorder
LNCRNA REGULATION OF GENE EXPRESSION & BEHAVIOR
This study is looking at how certain molecules in our cells, called long non-coding RNAs, might change the way our genes work and influence behavior, especially in people dealing with alcohol use disorder, to help us understand how alcohol affects the brain and find new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10870022 on NIH RePORTER |
What this research studies
This research investigates the role of long non-coding RNAs (lncRNAs) in regulating gene expression and behavior, particularly in the context of alcohol use disorder (AUD). It explores how both acute and chronic alcohol exposure can lead to changes in gene expression across various brain regions and cell types. By utilizing advanced techniques such as CRISPR, the study aims to uncover the biological functions of lncRNAs and their impact on alternative splicing, which is essential for the diversity of protein responses in the body. The findings could provide insights into how alcohol affects the brain and behavior, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are experiencing issues related to alcohol consumption or alcohol use disorder.
Not a fit: Patients who are under 21 years old or do not have any issues related to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for alcohol use disorder by targeting the molecular mechanisms involved in gene regulation and behavior.
How similar studies have performed: While the role of lncRNAs in gene regulation is an emerging field, previous studies have shown promising results in understanding their impact on various biological processes, suggesting potential for success in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Farris, Sean P — University of Pittsburgh at Pittsburgh
- Study coordinator: Farris, Sean P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.