How noggin affects brain growth and behavior
Regulation of Hippocampal Neurogenesis and Behavior by Noggin
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11042157
This study looks at how a protein called noggin helps grow new brain cells in a part of the brain that affects memory and learning, and it explores how things like exercise and antidepressants might boost noggin levels to improve thinking and mood.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11042157 on ClinicalTrials.gov |
What this research studies
This research investigates how the protein noggin influences the growth of new brain cells in the hippocampus and its impact on behavior, particularly cognitive functions. By studying adult mice, the researchers aim to understand how environmental factors like exercise can enhance noggin levels, potentially leading to improved cognitive performance and neurogenesis. The study explores the relationship between noggin, BMP signaling, and the effects of antidepressants on brain health and behavior. Patients may benefit from insights gained about how to enhance cognitive function and treat mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be adults experiencing cognitive decline or mood disorders.
Not a fit: Patients with neurological conditions unrelated to hippocampal function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cognitive impairments and mood disorders by targeting noggin and BMP signaling pathways.
How similar studies have performed: Previous research has shown that enhancing neurogenesis through similar mechanisms can lead to improved cognitive and emotional outcomes, suggesting a promising avenue for further exploration.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KESSLER, JOHN A — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: KESSLER, JOHN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.