How NLRP10 affects healing in skin infections caused by Leishmania
Official title: Regulation of wound healing pathways by NLRP10 in cutaneous Leishmaniasis
Funded at Cedars-Sinai Medical Center · NIH-10783649 · Data updated 2026-11-12
This study is looking at how a special immune receptor called NLRP10 helps heal skin wounds caused by cutaneous leishmaniasis, using mice to see what happens when NLRP10 is missing, with the hope of finding better treatments for people dealing with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 18, 2023 |
| Project end | September 17, 2025 |
| Funding year | 2023 |
| Award (this year) | $404,140 |
| NIH project number | 1R21AR083485-01 |
| Project ID | NIH-10783649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cutaneous leishmaniasis who experience prolonged skin ulcerations.
✕Less likely to help
Patients with cutaneous leishmaniasis who do not have significant wound healing issues may not benefit from this research.
What this research studies
This research investigates the role of a specific immune receptor, NLRP10, in the healing process of skin lesions caused by cutaneous leishmaniasis. By using a mouse model, the study aims to understand how the absence of NLRP10 affects wound healing, particularly in the presence of the Leishmania parasite. The researchers will explore the mechanisms behind NLRP10's involvement in regulating the repair of infected wounds, which could lead to new therapeutic strategies for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that accelerate healing for patients with cutaneous leishmaniasis.
How similar studies have gone: While the specific role of NLRP10 in wound healing is being investigated for the first time, similar studies have shown promise in understanding immune responses in wound healing.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Sutterwala, Fayyaz S. — Cedars-Sinai Medical Center
- Study coordinator: Sutterwala, Fayyaz S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.