How NLRC4 signaling affects immune responses
Innate NLRC4 signaling controls adaptive immune responses
This study is looking at a protein called NLRC4 to see how it helps our immune system fight off diseases like cancer and viral infections, and the findings could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11091629 on NIH RePORTER |
What this research studies
This research investigates the role of NLRC4, a protein involved in the immune system, particularly in how it influences the body's adaptive immune responses. By studying how NLRC4 interacts with immune cells, the research aims to understand its protective effects against conditions like cancer and viral infections. The approach includes examining the signaling pathways and cellular interactions that NLRC4 mediates, particularly focusing on its effects on T cells and antigen-presenting cells. Patients may benefit from insights gained into how to enhance immune responses against diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, cancer, or those at risk of severe viral infections.
Not a fit: Patients with non-immune related conditions or those not affected by cancer or viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune responses in patients with cancer or viral infections.
How similar studies have performed: Other research has shown promising results in understanding immune signaling pathways, suggesting potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sutterwala, Fayyaz S. — Cedars-Sinai Medical Center
- Study coordinator: Sutterwala, Fayyaz S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.