How nitrogen metabolism affects sleep and Alzheimer's disease
Official title: Nitrogen metabolism in sleep homeostasis and pathology
Funded at Kent State University · NIH-10931668 · Data updated 2026-11-12
This study is looking at how not getting enough sleep might affect our body's nitrogen processing and could be linked to Alzheimer's disease, especially by exploring certain compounds that help regulate sleep; it's for anyone interested in understanding how sleep and brain health are connected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kent State University NIH-funded |
| Lab location | 1 site (Kent, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $236,153 |
| NIH project number | 5R00NS118561-04 |
| Project ID | NIH-10931668 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing sleep deprivation or those at risk for Alzheimer's disease.
✕Less likely to help
Patients with sleep disorders unrelated to nitrogen metabolism or those not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between nitrogen metabolism and sleep, particularly focusing on how sleep deprivation may contribute to Alzheimer's disease. The study examines the role of polyamines, which are compounds linked to the urea cycle, in sleep regulation and neurodegeneration. By using advanced techniques like mass spectrometry, the researchers aim to identify specific metabolites involved in these processes and explore how manipulating polyamine levels can influence sleep patterns. This research could provide insights into potential therapeutic strategies for sleep-related disorders and Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sleep and potentially slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the link between sleep and metabolic processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Kent State University
Kent, United States Active
Researchers
- Principal investigator: Bedont, Joseph L — Kent State University
- Study coordinator: Bedont, Joseph L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.