How nitric oxide affects the way genes are spliced in cells
Official title: Nitric oxide as a novel regulator of alternative splicing
Funded at Case Western Reserve University · NIH-10916227 · Data updated 2026-11-12
This study is looking at how a molecule called nitric oxide affects a protein that helps control how genes are expressed, which could help us understand more about how our cells work and how genes are regulated.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30ES035247-02 |
| Project ID | NIH-10916227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to alternative splicing, such as certain cardiovascular diseases or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to RNA splicing or nitric oxide signaling may not benefit from this research.
What this research studies
This research investigates how nitric oxide, a signaling molecule, influences the process of alternative splicing in RNA, which is crucial for gene expression. By focusing on a specific protein known as polypyrimidine tract-binding protein (PTB), the study aims to understand how modifications caused by nitric oxide can alter the function of this protein and, consequently, the splicing of RNA. The research employs biochemical techniques to explore these modifications and their effects on cellular physiology, potentially leading to new insights into gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to gene expression and splicing abnormalities.
How similar studies have gone: While the role of nitric oxide in cellular processes is well-documented, the specific focus on its impact on alternative splicing through S-nitrosylation is a novel approach.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Schindler, Joseph Christian — Case Western Reserve University
- Study coordinator: Schindler, Joseph Christian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.