How nitric oxide affects gene regulation through methylation
Official title: Nitric oxide inhibits Iron(II)2-Oxogluterate dependent demethylases to regulate DNA and mRNA methylation
Funded at University of Illinois at Chicago · NIH-10999570 · Data updated 2026-11-12
This study is looking at how a molecule called nitric oxide affects the way our genes work by changing the way DNA and RNA are marked, which could help us understand new ways to treat certain diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $457,972 |
| NIH project number | 1R01GM155946-01 |
| Project ID | NIH-10999570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve dysregulated gene expression, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with stable gene expression profiles or those not affected by nitric oxide signaling may not benefit from this research.
What this research studies
This research investigates the role of nitric oxide (NO) in regulating gene expression by affecting the methylation of DNA and RNA. It explores how different concentrations of NO can inhibit specific enzymes that demethylate these molecules, potentially leading to changes in gene activity. By using advanced techniques like CRISPR, the study aims to understand the mechanisms behind NO's influence on gene regulation and its implications for various diseases. Patients may benefit from insights into how NO-related pathways could be targeted for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to abnormal gene expression.
How similar studies have gone: Previous research has shown promising results in understanding the role of nitric oxide in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Thomas, Douglas D. — University of Illinois at Chicago
- Study coordinator: Thomas, Douglas D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.