How nicotine pouch ingredients and strength affect addictiveness
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
This project looks at whether nicotine level and acidity in oral nicotine pouches make them more appealing and addictive for young adults and e-cigarette users.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11336289 on NIH RePORTER |
What this research studies
If you join, you'll try different nicotine pouches that vary in nicotine amount and acidity while researchers record how they feel and how the products affect the mouth and body. The team will measure nicotine levels in the blood and collect ratings of taste, irritation, and desire to use more. Sessions will be conducted in clinical settings with controlled product use and brief follow-up measurements. Results aim to link specific product features to how quickly nicotine is absorbed and how likely people are to keep using the pouches.
Who could benefit from this research
Good fit: Ideal candidates are young adults who currently use e-cigarettes or other nicotine products and are willing to try nicotine pouches in a supervised clinic setting.
Not a fit: People who do not use nicotine, those under 18, and pregnant individuals would likely not benefit from or be eligible for this work.
Why it matters
Potential benefit: If successful, the findings could help regulators limit product features that increase addictiveness and better protect young people.
How similar studies have performed: Previous laboratory studies show that higher nicotine and protonated (acidified) nicotine can increase uptake and appeal, but nicotine pouches are newer and long-term evidence is limited.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Han, Dae Hee — Emory University
- Study coordinator: Han, Dae Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.