How nicotine affects the misuse of prescribed opiates
Nicotinic and Insular Cortical Mechanisms Contributing to Opiate Misuse
['FUNDING_CAREER'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-10667440
This study is looking at how using nicotine might affect people who are prescribed opiates, especially in terms of their risk for becoming dependent on them or accidentally overdosing, to help find better ways to support those dealing with substance use issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-10667440 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between nicotine use and the misuse of prescribed opiates, focusing on how nicotine may influence the brain's insular cortex, which is involved in processing drug-related stimuli. The study aims to understand the mechanisms that contribute to the risk of opiate dependence and accidental overdose among patients who use both nicotine and opiates. By examining the effects of nicotine on brain function, the research seeks to uncover important insights that could inform treatment strategies for individuals struggling with substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are prescribed opiates and also use nicotine, particularly those involved in opioid treatment programs.
Not a fit: Patients who do not use nicotine or are not prescribed opiates may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment approaches for patients at risk of opiate misuse due to concurrent nicotine use.
How similar studies have performed: While the specific mechanisms being studied are underexplored, there is emerging evidence suggesting that nicotine affects brain function in ways that could impact opiate addiction, indicating potential for significant findings.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONEY, GREGORY CARL — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: LONEY, GREGORY CARL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.