How nickel exposure affects gene changes in human cells
Persistent transcriptional changes induced by nickel through epigenetic alterations
This study looks at how being around nickel, a common harmful substance, can change the way our genes work in skin and lung cells, which might lead to health problems like asthma, scarring, and cancer, helping us understand the lasting effects of nickel exposure even after we're no longer exposed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10732754 on NIH RePORTER |
What this research studies
This research investigates how exposure to nickel, a common environmental toxicant, leads to lasting changes in gene expression in human epithelial cells. The study focuses on the molecular mechanisms that result from nickel exposure, particularly how these changes can contribute to various health issues such as asthma, fibrosis, and cancer. By examining the effects of nickel on cell behavior, the research aims to uncover the long-term impacts of this exposure, which may persist even after the exposure has ended.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to nickel exposure, such as asthma, bronchitis, or certain types of cancer.
Not a fit: Patients who have not been exposed to nickel or do not have related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for diseases linked to nickel exposure, improving patient outcomes.
How similar studies have performed: Previous research has indicated that environmental toxins can lead to significant health issues, suggesting that this approach may yield valuable insights into the effects of nickel exposure.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Cuddapah, Suresh — New York University School of Medicine
- Study coordinator: Cuddapah, Suresh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.