How NF1 in nerve cells controls body metabolism
Genetic and molecular mechanisms of Nf1-dependent neuronal regulation of metabolism
This project looks at how changes in the NF1 gene in nerve cells can change whole-body metabolism for people with neurofibromatosis type 1.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11290420 on NIH RePORTER |
What this research studies
Scientists are using the fruit fly (Drosophila) to learn how the NF1 gene in neurons affects energy use and storage across the body. They will pinpoint the genes and signaling pathways that act downstream of NF1 to control metabolism. The team will map the neural circuits and identify neurotransmitters or peptides that carry metabolic signals from the brain to peripheral tissues. Because NF1 and many signaling mechanisms are conserved, findings in flies may reveal processes relevant to people with NF1.
Who could benefit from this research
Good fit: This research is relevant to people with neurofibromatosis type 1 (NF1), especially adults concerned about metabolic symptoms or who may join related future clinical studies.
Not a fit: People without NF1 or those seeking immediate clinical treatments are unlikely to get direct benefit from this basic, lab-based project.
Why it matters
Potential benefit: If successful, this work could reveal biological pathways that lead to new treatments or lifestyle strategies to manage metabolic problems in people with NF1.
How similar studies have performed: Previous studies have suggested NF1 can affect metabolism and animal models have provided useful clues, but the specific neuronal mechanisms targeted here remain largely unproven.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Tomchik, Seth M — University of Iowa
- Study coordinator: Tomchik, Seth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.