How NF-kB signaling affects cancer treatment with radiation therapy
Impact of Host NF-kB Signaling in Radiation Therapy
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10872255
This study is looking at how a specific pathway in the body affects the way radiation therapy works for cancer, especially by seeing if blocking this pathway can help boost the immune system's ability to fight tumors, which could lead to better treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10872255 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific signaling pathway, known as NF-kB, in the effectiveness of radiation therapy for cancer treatment. It focuses on understanding how this pathway influences the immune response, particularly the activity of CD8 T cells, which are crucial for attacking tumors. By using genetically modified mouse models, the researchers aim to determine how inhibiting this signaling pathway can enhance the anti-tumor effects of radiation therapy. The findings could lead to new strategies for improving cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing radiation therapy, particularly those with tumors responsive to CD8 T cell activity.
Not a fit: Patients with non-cancerous conditions or those not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation therapy options for cancer patients, potentially improving their treatment outcomes.
How similar studies have performed: While the specific approach of targeting N→C NF-κB signaling in radiation therapy is novel, similar studies have shown promising results in enhancing immune responses in cancer treatment.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIYAMOTO, SHIGEKI — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: MIYAMOTO, SHIGEKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient