How newborn olfactory neurons integrate into the brain's circuits
Functional integration of newborn olfactory sensory neurons in the healthy and regenerating olfactory system
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11221046
This study is looking at how new smell-related brain cells grow and connect in both healthy and recovering brains, which could help improve treatments for people with brain injuries or conditions that affect their sense of smell.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11221046 on ClinicalTrials.gov |
What this research studies
This research investigates how newly generated olfactory sensory neurons (OSNs) integrate into the brain's neural circuits, particularly focusing on their development and functionality in both healthy and regenerating olfactory systems. By using advanced imaging techniques, the study aims to understand the role of sensory input in the survival and integration of these neurons during their early development. The research could lead to insights on how to enhance brain repair strategies using stem cell-derived neurons for individuals with brain injuries or degenerative conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with acquired brain injuries or neurodegenerative conditions who may benefit from advancements in neuronal repair strategies.
Not a fit: Patients with conditions unrelated to olfactory sensory neuron function or those who are not within the age range of 21 years and older may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for repairing damaged brain areas, potentially improving outcomes for patients with brain injuries or neurodegenerative diseases.
How similar studies have performed: Other research has shown promise in understanding neuronal integration and repair mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEETHAM, CLAIRE ELIZABETH JANE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: CHEETHAM, CLAIRE ELIZABETH JANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury