How neutrophils move in the bloodstream to fight infections
Controlling the upstream migration of neutrophils by manipulating the function of Mac-1 and LFA-1
This study is looking at how certain white blood cells called neutrophils move from the blood to fight infections, and it aims to find ways to improve this process, which could help people with inflammatory conditions feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11073059 on NIH RePORTER |
What this research studies
This research investigates how neutrophils, a type of white blood cell, migrate from the bloodstream to areas of inflammation to combat infections. The study focuses on manipulating specific proteins, Mac-1 and LFA-1, that help neutrophils adhere to blood vessel walls and move towards infection sites. By understanding and controlling this migration process, the research aims to enhance the immune response during infections. Patients may benefit from insights that could lead to improved treatments for inflammatory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve inflammation or impaired immune responses.
Not a fit: Patients with stable, non-inflammatory conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the body's ability to fight infections more effectively.
How similar studies have performed: Other research has shown promising results in manipulating immune cell migration, suggesting that this approach may lead to significant advancements.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hammer, Daniel a — University of Pennsylvania
- Study coordinator: Hammer, Daniel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.