How neutrophil metabolism affects blood cell production after injury
Official title: Neutrophil Metabolism Regulates Hematopoiesis After Trauma
Funded at Ut Southwestern Medical Center · NIH-11098620 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils helps your body make new blood cells after an injury, which could lead to better ways to support your healing process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $569,019 |
| NIH project number | 5R01AI186118-02 |
| Project ID | NIH-11098620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced trauma and may be facing challenges in their recovery due to immune system deficiencies.
✕Less likely to help
Patients with chronic conditions unrelated to trauma or those who are not experiencing any immune response issues may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in regulating blood cell production after trauma. It focuses on how these cells communicate with the bone marrow to enhance the immune response following an injury. By utilizing advanced techniques like single-cell RNA sequencing and metabolomics, the study aims to understand the metabolic changes in neutrophils that influence hematopoiesis, the process of blood cell formation. Patients may benefit from insights into how their immune system responds to injuries and how this can be optimized for better healing.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients recovering from traumatic injuries by enhancing their immune response.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in recovery from trauma, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Tower, Robert — Ut Southwestern Medical Center
- Study coordinator: Tower, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.