How neutrophil extracellular traps affect lung health in cystic fibrosis and other lung diseases
Official title: The NET Impact on Lung Epithelia in Cystic Fibrosis and Mucoobstruction
Funded at University of Cincinnati · NIH-11049459 · Data updated 2026-11-12
This study is looking at how certain immune traps in the lungs might be causing damage and infections in people with cystic fibrosis and similar lung diseases, with the goal of finding new ways to help improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $756,875 |
| NIH project number | 1R01HL170156-01A1 |
| Project ID | NIH-11049459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cystic fibrosis or other mucoobstructive lung diseases who experience chronic lung inflammation and infections.
✕Less likely to help
Patients with lung diseases not characterized by mucoobstruction or those without significant inflammation may not benefit from this research.
What this research studies
This research investigates the role of neutrophil extracellular traps (NETs) in causing airway damage and infections in patients with cystic fibrosis and other mucoobstructive lung diseases. The study aims to understand the molecular mechanisms by which NETs contribute to inflammation and tissue injury in the lungs. By examining how NETs interact with key proteins in lung cells, researchers hope to uncover new insights into the inflammatory processes that worsen lung conditions. This could lead to the development of targeted therapies to improve lung health for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve respiratory health for patients with cystic fibrosis and similar conditions.
How similar studies have gone: Previous research has shown that targeting inflammatory processes in lung diseases can lead to significant improvements in patient outcomes, suggesting that this approach may also be effective.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Hudock, Kristin Mara — University of Cincinnati
- Study coordinator: Hudock, Kristin Mara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.