How neutrophil death affects infections caused by Candida albicans
Regulation of neutrophil death by GSDMD in Candida albicans infection
This study is looking at a protein called Gasdermin D to see how it affects the death of immune cells called neutrophils, which help fight infections like Candida albicans, especially in people with weakened immune systems; the goal is to find ways to keep these cells alive longer so they can better protect patients from serious infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11037656 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called Gasdermin D (GSDMD) in regulating the death of neutrophils, which are crucial for fighting off infections like those caused by Candida albicans, particularly in patients with weakened immune systems. The study aims to inhibit the death of neutrophils induced by Candida albicans to enhance their ability to kill the fungus, thereby potentially reducing severe infections in neutropenic patients. By understanding how GSDMD contributes to neutrophil death, the researchers hope to develop new therapeutic strategies to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised patients, particularly those with neutropenia, who are at high risk for Candida albicans infections.
Not a fit: Patients who do not have neutropenia or are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with neutropenia, reducing their risk of severe infections from Candida albicans.
How similar studies have performed: Other research has shown promising results in targeting neutrophil death mechanisms, suggesting that this approach may be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Luo, Hongbo R — Brigham and Women's Hospital
- Study coordinator: Luo, Hongbo R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.