How neurons use energy from mitochondria to function properly
Mitochondrial Energy Sensing and Neuronal Function
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11067352
This study looks at how brain cells use energy from tiny powerhouses called mitochondria to stay healthy and do their jobs, and it aims to find out how changes in this energy can affect important processes that keep these cells alive, which could help us understand and treat diseases that harm the brain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11067352 on ClinicalTrials.gov |
What this research studies
This research investigates how neurons rely on mitochondrial energy to perform their functions, focusing on the protonmotive force (PMF) that acts as a bioenergetic battery. It explores how fluctuations in PMF influence cellular processes like differentiation and autophagy, which are crucial for neuron survival. By developing tools for precise control of PMF in specific neuronal compartments, the research aims to uncover the relationship between mitochondrial function and neuronal health. This could lead to a better understanding of neurodegenerative diseases and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative conditions or those at risk of such diseases.
Not a fit: Patients with acute, non-neurological conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by enhancing our understanding of neuronal energy dynamics.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in neurons, indicating that this approach has potential for significant advancements.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOJTOVICH, ANDREW PHILLIP — UNIVERSITY OF ROCHESTER
- Study coordinator: WOJTOVICH, ANDREW PHILLIP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.