How neurons transport important mRNA for energy production
Axonal Transport of mRNA for Mitochondrial Proteins
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11058490
This study is looking at how brain cells keep themselves healthy by moving important messages and energy sources to different parts of the cell, focusing on a protein called synaptojanin2, which could help us understand how these cells work better or struggle when there are mutations.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058490 on ClinicalTrials.gov |
What this research studies
This research investigates how neurons maintain their health by transporting specific mRNA molecules into axons and dendrites, which are far from the cell body. The focus is on a protein called synaptojanin2, which helps carry mRNA for mitochondrial proteins along with mitochondria themselves. By studying both mouse and human cell lines with mutations in synaptojanin2, the research aims to catalog the types of mRNA involved and understand their role in neuronal function and energy supply. This could provide insights into how neurons adapt to local needs and maintain their health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting neuronal function or mitochondrial health.
Not a fit: Patients with conditions unrelated to neuronal mRNA transport or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by enhancing neuronal health and function.
How similar studies have performed: Other research has shown promising results in understanding mRNA transport mechanisms in neurons, suggesting this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWARZ, THOMAS L. — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: SCHWARZ, THOMAS L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.