How neurons repair DNA breaks and their impact on brain function
Mechanisms regulating the formation and repair of neuronal activity-induced DNA breaks in vivo and their effects on chromatin architecture and neuronal physiology
This study is looking at how brain cells react to what we sense around us and how this affects our behavior, especially focusing on how they fix certain types of DNA damage, which could help us understand conditions like autism and intellectual disabilities better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11132570 on NIH RePORTER |
What this research studies
This research investigates how neurons respond to sensory experiences by activating gene transcription programs that are crucial for developing adaptive behaviors. It focuses on understanding the mechanisms behind DNA double strand breaks (DSBs) that occur in neurons during this process and how these breaks are repaired. By studying signaling pathways in cultured mouse cortical neurons, the research aims to uncover the role of specific proteins in regulating these DSBs and their effects on gene expression. This knowledge could provide insights into neurodevelopmental disorders like autism and intellectual disabilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, such as autism spectrum disorder or intellectual disabilities.
Not a fit: Patients with neurodevelopmental disorders unrelated to neuronal activity or DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodevelopmental disorders by enhancing our understanding of neuronal function and repair mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding neuronal DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Madabhushi, Ram — Ut Southwestern Medical Center
- Study coordinator: Madabhushi, Ram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.